Here's our Windows NT Tip for.. April 29, 2003
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Deleting COM Ports
There are times when you might want to get rid of a Com port--at least temporarily. To do this, click Start, Settings, Control Panel and double-click Ports. Click the port you want to delete to select it and then click Delete.

After you delete the port and restart the computer, you may find that you still get an error event associated with the offending port. This can happen because there's still information about the port in the Registry. If this happens to you, you need to eliminate the port using RegEdit.

To do this, run RegEdit and navigate to

HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Serial\Parameters.

Under Parameters, you'll find each of your serial ports. Delete the one in question and choose Registry, Exit to close RegEdit. Now restart the computer.

If the port is active, it could appear again in Control Panel, Ports. If this happens, the only thing you can do is run your BIOS CMOS Setup utility and turn off the port.