Here's our Windows NT Tip for.. December 14, 1999
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Remove The Briefcase
If you always remove the Briefcase icon from the desktop, and would also like to remove the ability to create a new Briefcase, try this quick registry modification. Please note that if you are not comfortable directly working with the registtry, you may not want to try this one out.

Click Start, Run. Type

regedit

and press Enter. When RegEdit opens, navigate to HKey_Classes_Root. Now scroll down to Briefcase and click to select it. Choose Registry, Export Registry File. When the Export Registry File dialog box opens, type

Brief

and click Save.

Note: Do not skip this step--it is very important that you make this backup of the Briefcase key. If you do not, you won't be able to restore the Briefcase later.

With the Briefcase key saved, you can now choose Edit, Delete to delete the key. Finally, choose Registry, Exit to close RegEdit and apply your changes.

When you right-click the desktop and choose New, you'll see that there is no Briefcase option listed.

If you want to return Briefcase to your system, locate Brief.reg and double-click its icon to merge the original Registry entries with the current Registry.